Unrestrained Spindle Elongation during Recovery from Spindle Checkpoint Activation in cdc15-2 Cells Results in Mis-Segregation of Chromosomes

摘要

cdc15-2 cells failed to coordinate spindle elongation and kinetochore capture during recovery from Noc treatment. This was due to a failure in the cdc15-2 cells to accumulate Pds1p as well as in wild-type cells, indicating that timely progression through the cell cycle and proper expression of PDS1 is important in the presence of spindle damage.